[내논소 -2] 박성모 박사 신경 반점 Neurons! – 깜짝 논문왕 –

[내논소- 박성모 박사]

현재 제가 연구하는 분야와 관련이 있어서 읽다가 소개하게 되었습니다. 신경과학분야에서 연구방법은 다양한데요. 이번 연구는 행동실험과 그 변화를 설명하기위해 RNA transcriptome을 사용하여, 치료 타겟을 제안 하는 내용으로 생각됩니다. ^^

 

 

 

2023 Aug 31;42(9):113066.

doi: 10.1016/j.celrep.2023.113066. Online ahead of print.

 

Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction

 

Abstract

Fear-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive fear extinction. We find that, already before fear conditioning, specific morphological, electrophysiological, and transcriptomic patterns of cortical and amygdala pyramidal neurons predispose to fear-related disorders. Finally, by using an optogenetic approach, we show the possibility to rescue inefficient fear extinction by activating infralimbic pyramidal neurons and to impair fear extinction by activating prelimbic pyramidal neurons.

 

Keywords: CP: Cell biology; CP: Neuroscience; amygdala; cellular excitability; dendritic spines; infralimbic cortex; medial prefrontal cortex; optogenetic stimulations; post-traumatic stress disorders; prelimbic cortex; transcriptome.

 

저널 토론방: https://open.kakao.com/o/gBQ0CWTd

 

1068 명 회원

 

 

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