[๋‚ด๋…ผ์†Œ -2] Bio-macromolecular Bioadhesive Review ๐Ÿ’Ž – ์™•์ˆœํ™ ์ฒœ์‚ฌ –

[๋‚ด๋…ผ์†Œ- ์ƒ๋ฌผ์ ํ•ฉ์ฒด ๋ฆฌ๋ทฐ]

์•ˆ๋…•ํ•˜์„ธ์š” ๋…ผ๋ฌธ ์ฒœ์‚ฌ ์™•์ˆœํ™์ž…๋‹ˆ๋‹ค!

์š”์ฆ˜ ํ•™๋ถ€์—ฐ๊ตฌํ•˜๋ฉด์„œ ์ ‘๊ทผํ•˜๊ฒŒ ๋œ ํ† ํ”ฝ ์ค‘ ํ•˜๋‚˜๊ฐ€ ์ƒ๋ฌผ์ ํ•ฉ์ฒด๋ฅผ ์—ฌ๋Ÿฌ๋ถ„์—๊ฒŒ ์†Œ๊ฐœ๋“œ๋ฆฌ๊ณ  ์‹ถ์œผ๋ฉฐ ์ด ๋ถ„์•ผ์˜ ์ „๋ฌธ๊ฐ€ ์˜๊ฒฌ๋„ ๋“ค๊ณ  ์‹ถ์–ด์„œ ์˜ฌ๋ ธ์Šต๋‹ˆ๋‹ค. UCLA ๊ต์ˆ˜์ง„ collabํ•ด์„œ ์ถœํŒํ•˜์‹  bioadhesive ๋…ผ๋ฌธ์„ ์†Œ๊ฐœ๋“œ๋ฆฌ๊ฒ ์Šต๋‹ˆ๋‹ค.

 

[๋…ผ๋ฌธ ์ •๋ณด]

Bio-macromolecular design roadmap towards tough bioadhesives

Hossein Montazerianย abc,ย Elham Davoodiย abcd,ย Avijit Baidyaย e,ย Maryam Badvย bfg,ย Reihaneh Haghniazย c,ย Arash Daliliย h,ย Abbas S. Milaniย h,ย Mina Hoorfarย hi,ย Nasim Annabiย *ae,ย Ali Khademhosseiniย *cย andย Paul S. Weiss; DOI:ย 10.1039/D2CS00618Aย (Review Article)ย Chem. Soc. Rev., 2022,ย 51, 9127-9173

 

[๋…ผ๋ฌธ ์š”์•ฝ]

์ˆ˜์ˆ  ํ›„ ์‚ฌ์šฉํ•˜๋Š” ํŠธ์•„๋ฃจ๋งˆํ‹ฑ ํ•œ ์ƒ์ฒ˜ ๋ด‰ํ•ฉ๋ฒ• ๋Œ€์ฒดํ•  ์ˆ˜ ์žˆ์œผ๋ฉฐ ์ฒœ์—ฐ ์žฌ๋ฃŒ๋กœ ํด๋ฆฌ๋จธ (polyethylene glycol, polyurethanes, cyanoacrylates etc.)๋‚˜ ๋ฐ”์ด์˜ค(chitosan, hyaluronic acid, gelatin, fibrin etc.)ย  ์ ํ•ฉ์ฒด์˜ ์—ฌ๋Ÿฌ activation/coupling mechanism, ๊ณต์ • ๊ณผ์ •๊ณผ ์žฌ๋ฃŒ๋งˆ๋‹ค์˜ ๊ฐ•๋„, ์žฅ๋‹จ์ , ๋ณธ ๋ถ„์•ผ์˜ ๋‚œ๊ด€๊ณผ ๋ฏธ๋ž˜ ์—ฐ๊ตฌ๋™ํ–ฅ์— ๋Œ€ํ•œ ์ „์ฒด์ ์ธ ๋…ผ๋ฌธ์ž…๋‹ˆ๋‹ค.

 

์ด ๋…ผ๋ฌธ์˜ ํ•˜์ด๋ผ์ดํŠธ๊ฐ€ ์•„๋ž˜์™€ ๊ฐ™์Šต๋‹ˆ๋‹ค:

 

1) bioadhesive๊ฐ€ ํฌ๊ฒŒ ์ฒœ์—ฐ (natural) ์žฌ๋ฃŒ๋‚˜ ์ธ์กฐ (synthetic) ์žฌ๋ฃŒ๋กœ 2๊ฐ€์ง€๋กœ ๋‚˜๋ˆด๊ณ  natural๊ณผ synthetic hydrogel์ด ๊ทธ์ค‘์— ์ œ์ผ ๋งŽ์ด ์—ฐ๊ตฌํ•˜๊ณ  ์žˆ๋Š” bioadhesive๋‚˜ ์ –๊ฑฐ๋‚˜ ๊ธฐ๋ฆ„์ง„ ํ‘œ๋ฉด์— ์ž˜ ๋ถ€์ฐฉํ•˜์ง€ ์•Š๋‹ค๋Š” ๋‹จ์ ์ด ์žˆ๋‹ค.
2) ํž˜ ์ œ๊ฑฐ ํ›„์— ๋ถ„์ž ๊ฒฐํ•ฉ ๋งํฌ๋“ค์ด ์žฌ๊ฒฐํ•ฉ ํ•  ์ˆ˜ ์žˆ๋Š” self healing hydrogel๋“ค์˜ ๊ณต์ • approach ๋‹ค์–‘ํ•˜๊ฒŒ ํ•ด์•ผ ํ•œ๋‹ค

 

 

3) bioadhesive์˜ ํฌ๊ธฐ์™€ ๋ชจ์–‘์ด crosslinker์˜ ๊ธธ์ด์— ์˜ํ–ฅ ํฌ๊ฒŒ ๋ฐ›๋Š”๋‹ค
4) bioadhesive์˜ cohesion์™€ adhesion ํž˜ ๋ฟ๋งŒ ์•„๋‹ˆ๋ผ 2์ฐจ๋กœ ์ง€์›ํ•  ์ˆ˜ ์žˆ๋Š” mechanical ์„ค๊ณ„๋“ค๋„ ์ค‘์š”ํ•˜๋‹ค. ๋…ผ๋ฌธ์—๋Š” ์ƒํ”ผ ์งํˆฌํ•˜๋Š” micro needle๊ฐ€ ์กฐ์ง ๋‚ด์— swelling ๋ ์ˆ˜ ์žˆ๋Š” ์—ฌ๋Ÿฌ ์„ค๊ณ„๋ฅผ ์ œ์‹œํ–ˆ๋‹ค.

 

 

5) ํ™ํ•ฉ๊ณผ ๊ฐ€๊นํ•œ ๋ถ€์ฐฉ ๊ฐ•๋„๋Š”ย  catechol ์ฒ˜๋ฆฌ๋กœ ๋„๋‹ฌํ•  ์ˆ˜ ์žˆ์œผ๋‚˜ ์•„์ง ์™„์ „ mimic ํ•  ์ˆ˜ ์—†๋‹ค.

 

 

 

 

โ€˜K-BioX Biomedical ์ €๋„ ๋””์Šค์ปค์…˜ ํฌ๋Ÿผโ€™ ์นดํ†ก ์˜คํ”ˆ์ฑ„ํŒ…๋ฐฉ์—์„œ ๋…ผ๋ฌธ ๊ณต์œ , ๋…ผ๋ฌธ ๋…ผ์˜, ํ˜„์žฌ ๋ฐ”์ด์˜ค ๊ธฐ์ˆ  ์—ฐ๊ตฌ ๋“ฑ๋“ฑย  ๋งŽ์ด ๋…ผ์˜ํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ๋” ๋งŽ์€ ๋…ธ๋ฌธ ๋””์Šค์ปค์…˜์„ ์›ํ•˜์‹ ๋‹ค๋ฉด:

https://open.kakao.com/o/gBQ0CWTd

์œ„ ๋งํฌ๋ฅผ ํด๋ฆญํ•˜๊ณ , ํ˜„์žฌ 1100๋ช… ์ด์ƒ์ด ํ•จ๊ป˜ํ•˜๊ณ  ์žˆ๋Š” ์˜คํ”ˆ์ฑ„ํŒ…๋ฐฉ์— ์ฐธ์—ฌํ•˜์„ธ์š”!

 

ํŽธ์ง‘: ์™•์ˆœํ™

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