[๋‚ด๋…ผ์†Œ -3] Electric bioadhesive Interface ๐Ÿ’Ž – ์™•์ˆœํ™ ์ฒœ์‚ฌ –

[๋‚ด๋…ผ์†Œ- ์ „๊ธฐ์„ฑ ์ƒ์ฒด ๊ณ„๋ฉด]

์•ˆ๋…•ํ•˜์„ธ์š” ๋‹ค์‹œ ๋Œ์•„์˜จ ๋…ผ๋ฌธ ์ฒœ์‚ฌ ์™•์ˆœํ™์ž…๋‹ˆ๋‹ค!

์ง€๋‚œ bioadhesive ๋…ผ๋ฌธ ์ด์–ด์„œ ์‹ ๊ทœ ๊ฐœ๋ฐœํ•œ bioadhesive ์˜ ์ผ์ข… electronic bioadhesive๋ฅผ ์—ฌ๋Ÿฌ๋ถ„์—๊ฒŒ ์†Œ๊ฐœ๋“œ๋ฆฝ๋‹ˆ๋‹ค.

 

[๋…ผ๋ฌธ ์ •๋ณด]

Electrical bioadhesive Interface for Bioelectronics

Deng, J., Yuk, H., Wu, J.ย et al.ย Electrical bioadhesive interface for bioelectronics.ย Nat. Mater.ย 20, 229โ€“236 (2021). https://doi.org/10.1038/s41563-020-00814-2

 

[๋…ผ๋ฌธ ์š”์•ฝ]

๋ชธ์— ์ž…ํž ์ˆ˜ ์žˆ๋Š” ์˜๋ฃŒ๊ธฐ๊ธฐ์˜ ์ค‘์š”ํ•œ ํŠน์ง• ์ค‘ ํ•˜๋‚˜๊ฐ€ ์ƒ์ฒด์— ๋ถ€์ฐฉํ•˜๋Š” ๊ฒƒ์ด๋‹ค. ํ•˜์ง€๋งŒ ๋ชธ์˜ ์—ญ๋™์„ฑ, ํ‘œ๋ฉด ์ˆ˜๋ถ„ย  ๋“ฑ ํ‘œ๋ฉด์˜ ํŠน์„ฑ๊ณผ ๋ฉด์  ๋ณ€ํ™” ๋•Œ๋ฌธ์— ํŠผํŠผํ•œ ๋ถ€์ฐฉ ๊ธฐ์ˆ  ์•„์ง ๋ฉ€์—ˆ์œผ๋ฉฐย  ์‹ ํ˜ธ ์ „๋„ ํšจ์œจ์ด ๋–จ์–ด๊ฒŒ ํ•˜๋Š” ์ˆ˜์ˆ  ๊ฐ™์€ ๊ฐ•์ œ ๋ถ€์ฐฉ ๋ฐฉ๋ฒ•๋ฐ–์— ์—†๋‹ค.

MIT์— ์žˆ๋Š” ๊ณผํ•™์ž๋“ค์ด ํ‘œ๋ฉด ํŠน์„ฑ์˜ ์˜ํ–ฅ ์—†์ด ์ƒ์ฒด์— ๋ถ€์ฐฉํ•  ์ˆ˜ ์žˆ๊ณ  ์ „๋„ ํšจ์œจ๊นŒ์ง€ ์œ ์ง€ํ•  ์ˆ˜ ์žˆ๋Š” ์ „๊ธฐ์„ฑ ์ƒ์ฒด ๊ณ„๋ฉด์„ ๊ฐœ๋ฐœํ–ˆ๋‹ค.

 

๋ถ€์ฐฉ ๋ฉ”์นด๋‹ˆ์ฆ˜:ย 

Graphene nanocomposite๋กœ ์ฑ„์šด ๊ณ„๋ฉด์ด ํ‹ฐ์Šˆ์™€ ์ ‘์ด‰ํ•  ๋•Œ ์•ก์ฒด (ํ”ผ,๋ฌผ ๋“ฑ) ๊ณ„๋ฉด ์ชฝ์œผ๋กœ ๋นจ์•„๋“ค์—ฌ์„œ ๋ฑ…์ฐฝํ•˜๊ณ  ํ‹ฐ์Šˆ ํ‘œ๋ฉด๊ณผ mechanical interlock ํ•˜๊ณ  ์ด‰์ด‰ํ•˜๊ณ  ๋ง๋ž‘๋ง๋ž‘ํ•œ ์‹ ์ด‰์„ฑ ์žˆ๋Š” hydrogel๋กœ ๋ณ€ํ•œ๋‹ค.ย  ์ถ”๊ฐ€ ๋ถ€์ฐฉ๋ ฅ์„ ์œ„ํ•ด ์ฃผ์–ด์ง„ hydrogel๋ฅผ polyacrylic acid์™€ N-hydroxysuccinimide ๊ต์ฐจ ํด๋ฆฌ๋จธ ๋„คํŠธ์›Œํ‚น ์‹œ์ผœ์„œ graphene oxide – polyvinyl alcohol – polyacrylic acid – N hydroxysuccinimide (GO-PVA-PAA-NHS) ๋„คํŠธ์›Œํฌ๊ฐ€ ํ˜„์„ฑ๋œ๋‹ค.

 

Wearable bioelectronics์™€์˜ ๋ถ€์ฐฉ:

Bioelectronic์™€ bioadhesive ํด๋ฆฌ๋จธ๋ฅผ covalent crosslinking ํ•  ์ˆ˜ ์žˆ๊ฒŒ primary amine group๋ฅผ doping ํ•œ๋‹ค. PVA์—์„œ rGO-PVA๋กœ ํ™˜์›ํ•จ์œผ๋กœ์จย  ์ „๋ฅ˜ ์ „๋„์‹œํ‚ค๋Š” ๋ฉ”์ปค๋‹ˆ์ฆ˜์ด๋ผ ์ฃผ๋กœ crosslinking ์žก์•„์ฃผ๋Š” ์ˆ˜์†Œ๊ฒฐํ•ฉ์— ์˜ํ–ฅ์— ๋ฏธ์น˜์ง€ ์•Š์•„ bioadhesive์˜ mechanical ํž˜์— ํฐ ๋ฌธ์ œ๊ฐ€ ์—†๋‹ค.ย  ๋ถ€์ฐฉ ์‹œ ํ‹ฐ์Šˆ ํ‘œ๋ฉด์— ์žˆ๋Š” ์•ก์ฒด๋ฅผ anisotropically ํก์ˆ˜ํ•ด์„œ ๋ฑ…์ฐฝํ•˜๋ฉด์„œ ํ‹ฐ์Šˆ์™€ covalent binding, electrostatic interaction์™€ ์ˆ˜์†Œ ๊ฒฐํ•ฉ ๋“ฑ ์—ฌ๋Ÿฌ weak force์˜ ๊ฒฐํ•ฉ์ด ์ผ์–ด๋‚œ๋‹ค.

 

์ ‘์ฐฉ ๋ฐ ์ „๋„ ์„ฑ๋Šฅ:ย 

 

interfacial ํž˜/ shear strength :

์‹ฌ์žฅ: > 420Jm-2 / >110kPa (์ผ๋ฐ˜: 1.55Jm-2 / 0.21kPa) ์•ฝย  270๋ฐฐ ๋ฐ 523๋ฐฐ ์ฆ๊ฐ€

ํ”ผ๋ถ€: > 270 Jm-2 / >60 kPa (์ผ๋ฐ˜: 0.34 Jm-2/ 0.19kPa) ์•ฝย  794๋ฐฐ ๋ฐ 315๋ฐฐ ์ฆ๊ฐ€

๊ทผ์œก: > 230 Jm-2 / >50kPa

์‹ ๊ฒฝ: > 260 Jm-2 / >70kPa

 

์ „๋„๋ฅผ ์ง€ํ‘œํ•˜๋Š” LED๋ฅผ ๋ฐ•๋™ํ•˜๊ณ  ์žˆ๋Š” ๋ผ์ง€ ์‹ฌ์žฅ์— ๋ถ€์ฐฉํ•œ ์ ‘์ฐฉ์ฒด์™€ ์—ฐ๊ฒฐํ•ด์„œ LED์˜ ๋ฐ๊ธฐ์™€ ๋ฐ˜์ง์— ๋”ฐ๋ผ์„œ ์ „๋„์„ฑ์„ ์ธก์ •ํ•œ๋‹ค.ย  E-bioadhesive ์ข‹์€ ์ „๋„์„ฑ์„ ๋Š์ž„์—†๋Š” LED์˜ ๋ฐ๊ธฐ๋ฅผ ๋ณด์—ฌ์ค„ ์ˆ˜ ์žˆ๋‹ค.ย  ย ๊ทธ๋ฆฌ๊ณ  E-bioadhesive์˜ ์ „๋„์„ฑ๋„ย  37๋„ PBS์— 14์ผ ์—ฐ์† ๋‹ด๊ธด ์ฑ„๋กœย  ์ธก์ •์„ ํ–ˆ์œผ๋ฉฐ ์ƒ์ฒด ํ‹ฐ์Šˆ๋ณด๋‹คย  ๋†’๊ฒŒ ๋‚˜์™„๋‹ค ํ•œ๋‹ค. (>2.7Sm-1)

 

์ƒ์ฒด์ ํ•ฉ์„ฑ:

๋งˆ์šฐ์Šค epidermal์—ย  14 ๋™์•ˆ ์‚ฝ์ž…ํ•œ ๋’ค์— ํฌ๊ฒŒ ์ผ์–ด๋‚œ ์ƒ์ฒด ๋ฐ˜์‘์ด ์—†๋‹ค๋Š” ๊ฒƒ์„ ๋ฐํ˜”๋‹ค. Fibroblast ํ˜•์„ฑ ๋ฐ”์ด์˜ค๋งˆ์ปค์™€ ๋ฉด์—ญ ์„ธํฌ ๋ฐ”์ด์˜ค๋งˆ์ปค ๋ฐœํ˜„๋„ significant ๋ณ€ํ™”๊ฐ€ ์—†๋‹ค

 

 

๋ณธ์—ฐ๊ตฌ๋Š” ์ƒ์ฒด์ ํ•ฉ, ๋†’์€ ์ „๋„์„ฑ๊ณผ ์‰ฝ์„ธ ์ œ๊ฑฐํ•  ์ˆ˜ ์žˆ๋Š” ์ƒ์ฒด ์ ‘์ฐฉ์ฑ„๋ฅผ ๊ฐœ๋ฐœํ–ˆ์œผ๋ฉฐ ์ž…ํž ์ˆ˜ ์žˆ๋Š” ๋งˆ์ดํฌ๋กœ ์˜๋ฃŒ๊ธฐ๊ธฐ์˜ ์ฃผ๋กœ ๋ถ€์ฐฉ ๋ฐฉ๋ฒ•์ด ๋  ์ˆ˜ ์žˆ๋‹ค.

 

 

โ€˜K-BioX Biomedical ์ €๋„ ๋””์Šค์ปค์…˜ ํฌ๋Ÿผโ€™ ์นดํ†ก ์˜คํ”ˆ์ฑ„ํŒ…๋ฐฉ์—์„œ ๋…ผ๋ฌธ ๊ณต์œ , ๋…ผ๋ฌธ ๋…ผ์˜, ํ˜„์žฌ ๋ฐ”์ด์˜ค ๊ธฐ์ˆ  ์—ฐ๊ตฌ ๋“ฑ๋“ฑย  ๋งŽ์ด ๋…ผ์˜ํ•˜๊ณ  ์žˆ์Šต๋‹ˆ๋‹ค. ๋” ๋งŽ์€ ๋…ธ๋ฌธ ๋””์Šค์ปค์…˜์„ ์›ํ•˜์‹ ๋‹ค๋ฉด:

https://open.kakao.com/o/gBQ0CWTd

์œ„ ๋งํฌ๋ฅผ ํด๋ฆญํ•˜๊ณ , ํ˜„์žฌ 1122๋ช… ์ด์ƒ์ด ํ•จ๊ป˜ํ•˜๊ณ  ์žˆ๋Š” ์˜คํ”ˆ์ฑ„ํŒ…๋ฐฉ์— ์ฐธ์—ฌํ•˜์„ธ์š”!

 

ํŽธ์ง‘: ์™•์ˆœํ™

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