조쌍구 교수

Introduction

건국대학교 줄기세포재생공학과 조쌍구 교수팀 (분자세포리프로그래밍 (Molecular & Cellular Reprogramming) 실험실) 은 발생, 세포사멸 (apoptosis), 자가소화작용 (autophagy) 및 세포리프로그래밍에 관련된 세포 신호전달 과정을 여러 가지 분자세포생물학적 방법으로 연구하고 있습니다. 또한, 다양한 물질을 이용한 줄기세포 및 암줄기세포 리프로그래밍 조절, 세포 신호조절을 통한 세포 내 다양한 생리 현상 연구, 세포 내 중요한 기작인 apoptosis, autophagy, cancer stem cell, iPSC (induced pluripotent stem cell) 관련 신호전달 분석 및 조절 연구를 진행하고 있습니다. 이들 연구를 바탕으로 얻어진 분자세포생물학적 연구 결과를 질환 치료제 및 생리활성 물질 개발, 줄기세포를 이용한 맞춤 세포 치료제 개발 등에 적극적으로 응용하여 상용화 기술 개발에 매진하였습니다.

Major Publications

1. Soo Bin Lee1†, Ahmed Abdal Dayem1†, Sebastian Kmiecik2, Kyung Min Lim, Dong Sik Seo3, Hyeong-Taek Kim3, Polash Kumar Biswas1, Minijae Do, Deok-Ho Kim, Ssang-Goo Cho1*. Efficient improvement of the proliferation, differentiation, and anti-arthritic capacity of mesenchymal stem cells by simply culturing on the immobilized FGF2-derived peptide, 44-ERGVVSIKGV-53. (submitted to JAR (20220722), Accepted (20230927) Journal of Advanced Research (ISSN: 2090-1232) In press. https://authors.elsevier.com/sd/article/S2090-1232(23)00290-4
2. Dong Hyun Kim, Kyung Min Lim, Jae-Min Cho, Hyo Jin Park, Seungyeon Hwang, Ahmed Abdal Dayem, Ye Jin Jeong, Yeokyung Shin, Yongpyo Hong, Kwonwoo Song, Ssang-Goo Cho* and Jae-Yol Lim*. Ductal delivery of extracellular vesicles promote the recovery from salivary gland inflammation. Journal of Controlled Release 357 (2023) 235-248. https://doi.org/10.1016/j.jconrel.2023.03.055.
3.  Ahmed Abdal Dayem, Soo Bin Lee, Kyung Min Lim, Aram Kim, Ha-Youn Shin, Balachandar Vellingiri, Young Bong Kim, and Ssang-Goo Cho*. Bioactive Peptides for boosting stem cell culture platform: Methods and applications. Biomedicine & Pharmacotherapy 160 (2023) 114376. https://doi.org/10.1016/j.biopha.2023.114376
4. Kyung Min Lim, Ji-Hye Han, Yoonjoo Lee, Junghee Park, Ahmed Abdal Dayem, Seung-Hyun Myung, Jongyub An, Kwonwoo Song, Geun-Ho Kang, Sejong Kim, Sangwoo Kwon, Kyung Sook Kim, Tae-Hyoung Kim, Ssang-Goo Cho. Rapid production method with increased yield of high-purity extracellular vesicles obtained using extended mitochondrial targeting domain peptide. Journal of Extracellular Vesicles / Volume 11, Issue 10, 12274 https://doi.org/10.1002/jev2.12274 Journal of Extracellular Vesicles. online published. (2022) IF: 25
5. Kyung Min Lima,†, Sehee Kima,†, Jeonghun Yeomb,†, Yujin Choia, Yoonjoo Leea, Jongyub Ana, Minchan Gila, Ahmed Abdal Dayema, Kyeongseok Kima, Geun-Ho Kanga, Aram Kimcc, Kwonho Honga, Kyunggon Kimb,d,e,*, Ssang-Goo Choa,* Advanced, 3D Dynamic Culture System with Transforming Growth Factor-β3 Enhances Production of Potent Extracellular Vesicles with Modified Protein Cargoes via Upregulation of TGF-β Signaling, Journal of Advanced Research (ISSN: 2090-1232) Volume 47, May 2023, Pages 57-74., https://doi.org/10.1016/j.jare.2022.09.005, . online published (2022).
6. Kwonwoo Song1†, Ahmed Abdal Dayem1†, Yujin Choi1†, Soobin Lee1†, Kyung Min Lim1, Sehee Kim1, Jongyub An1, Hanbit Bong1, Soo Bin Jang1, Tak-Il Jeon1, Hyojin Park1, Yeokyung Shin1, Jeong Ik Lee3, Geun-Ho Kang4, Sejong Kim4, Aram Kim2*, Ssang-Goo Cho1,4*. Superior therapeutic activity of TGF-β-induced extracellular vesicles against interstitial cystitis. Journal of Controlled Release 348 (2022) 924-937.https://doi.org/10.1016/j.jconrel.2022.06.045

Education and Professional Experiences

Ph. D., Biochemistry, Oxford University, Oxford
M. S., Microbiology, Seoul National University
B. A., Microbiology, Seoul National University

SNU Distinguished Professor, 2017, Seoul National University
Professor, School of Biological Sciences, 2013, Seoul National University
Director, Center for RNA Research, 2012, Institute for Basic Science
SNU Distinguished Fellow, 2010-2016, Seoul National University
Associate Professor, School of Biological Sciences, 2008-2013, Seoul National University
Assistant Professor, School of Biological Sciences, 2004-2008, Seoul National University
Research Associate Professor, Advanced Training Program for Biological Sciences, 2001-2004, Seoul National University
Postdoc Fellow, Howard Hughes Medical Institute, 1999-2001, University of Pennsylvania

Contact | Office Tel. : 02-450-4207  Email : ssangoo@konkuk.ac.kr Homephage : https://cafe.naver.com/kumcbp?iframe_url=/MyCafeIntro.nhn%3Fclubid=23179990

작성 및 편집 |  동국대학교 변용주